New research indicates that people who stop using popular slimming jabs like Wegovy and Mounjaro may regain lost weight far faster than those who halt traditional diet and exercise programs.
Findings released in a leading medical journal points out that while obese people often shed about a fifth of their body weight while on the medication, the weight returns at an average rate of nearly a kilo each month after stopping.
"Individuals purchasing these treatments must be cognizant of the risk of quick rebound weight gain when the treatment concludes," cautioned researcher Dr. Susan Jebb.
Such speed of regain suggests a reversion to starting mass within about a year and a half.
Analyzing Therapies
The analysis, which reviewed dozens of trials involving thousands of participants, compared the results of these new drugs with other pills.
Researchers note that individuals who lose weight through dieting usually see a slower creep back—approximately 100 grams monthly—once they finish.
Explaining the Rapid Rebound
Nutrition scientists suggest the mode of action of the jabs is key to understanding the accelerated weight return.
The injections mimic a natural hormone called glucagon-like peptide-1, which moderates feelings of fullness.
"Sustained high doses of GLP-1 levels several times higher than normal could lead to the system to generate a reduced amount of its endogenous hormone, and may also reduce responsiveness to its effects," said Dr. Adam Collins, a nutrition expert.
"Stopping of this hormone supplement results in appetite is uncontrolled, making overeating a significant risk."
A Lifelong Issue?
Health authorities recommend the jabs for individuals with weight-linked medical conditions, accompanied by recommended lifestyle changes.
Many experts contend that, given the high risk of weight regain, the treatment might need to be long-term.
This perspective is reinforced by drug manufacturers, who state that the findings "underscore the chronic character of excess weight," comparing it to managing diseases like diabetes.
User Experiences
People who have discontinued the medication explain a intense resurgence of appetite.
"I experienced a trigger flipping and I was suddenly ravenous," described one woman.
This difficulty is worsened if patients have not established lasting dietary or behavioural changes during therapy.
Significant Use
Recent estimates suggest that a significant number of people in the UK have tried weight-loss jabs in the last 12 months, with desire continuing to grow.
- Use is more common among women compared to males.
- The middle-aged age group shows the greatest usage rates.
- Many access the medications through private prescriptions rather than the NHS.
In conclusion, researchers emphasize that while GLP-1 drugs are effective tools for shedding pounds, they are not a standalone solution and maintained weight loss hinges on combined lifestyle support.
